Antidepressant Endep

Endep is the part of one of the antidepressants’ group called tricyclic antidepressants (TCAs). It is designed to cross the Blood Brain Barrier (BBB) which has the ability to alter the levels neurotransmitters that are responsible for the symptoms of depression and other psychological disorders. It is often called by the generic name Amitriptyline. Sometimes this medication can lead to dizziness or drowsiness. An interaction between alcohol and this drug can be hazardous. Therefore, it should never be taken together. The neurotransmitter altered using this drug is usually serotonin (the one responsible for joy). There are many other uses as well of this medication, some are under investigation. It is also helpful in relieving tension or anxiety in individuals. As it is from the tricyclic antidepressants (TCAs), it can bring about several side effects as well compared to other groups. The common ones are weakness, nausea, and vomiting.

Uses of Endep

Some of the known medical uses of this medication are as follows:

• Major depressive disorder
• Headaches cause by tension
• Treating Parkinson’s disease’s early stage
• Irritable bowel syndrome
• Nocturnal enuresis
• Fibromyalgia
• Neuropathic pain
• Attention deficit hyperactivity disorder (ADHD)
• Bilary dyskinesia
• Chronic cough
• Cyclic vomiting syndrome
• Urinary inconsistence
• Insomnia
• Eating disorders

Side effects of Endep

Psychotropic medications cannot go without side effects. Especially if it belongs to the TCAs, there can be many unnecessary side effects that can affect the daily functioning of the patient. Some of them are as follows:

Major side effects:

• Feeble or weak pulse
• Tiredness
• Sleepiness
• Muscle weakness
• Low temperature of the body
• Muscle aches
• Clumsiness
• Drowsiness
• Yellow skin and eyes
• Weight loss or gain
• Weakness in feet, legs, hands, or arms
• Presence of blood in vomit
• Abdominal pain
• Unusual pale colour of the skin
• Unusual bruising or bleeding
• Trembling, or other related problems with muscle coordination or control
• Chewing movements that could not be controlled
• Trouble in breathing
• Trouble in sleeping
• Acting too excited without any control over it
• Face getting all Puffy
• All of a sudden losing consciousness
• Stupor
• Ulcers, white spots, or sores on the mouth or lips

Minor side effects:

• Milking breasts occurring all of a sudden
• Parotid glands getting swelled up
• Skin rashes
• Severe degree of sunburn
• Skin gets discoloured
• Losing the sense to taste

Contraindications

Under certain circumstances, this medication should not be permitted or prescribed to the patient. They are:

• Epileptic seizure
• Closed eye glaucoma
• Wide-angle glaucoma
• Difficulty in bowel movement (chronic)
• Recent history of heart attack
• Having an abnormal rhythm of the heart
• Intestine paralysis
• Liver diseases

Endep and Pregnancy

The FDA had assigned Endep to the pregnancy category C. This means that animal research studies have shown significant risks. Only if the benefits are far greater than the potential risks, this drug should be administered.

Mode of Ingestion

It is found in the form of tablets that need to be taken through the mouth.